Treatment Options for Metastatic Prostate Cancer

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Most countries have preventative examinations for prostate cancer. Every 2 years, men over 50 have a PSA blood test, and if there are abnormalities, further testing is done. With this approach, malignancy is more likely to be detected at an early stage. But not all men are examined, so the disease is sometimes detected at a stage of metastasizing. In such cases, radiotherapy, chemotherapy, and hormone therapy become the primary treatment options, and if these no longer work, alternative techniques are applied.

General principles of prostate cancer treatment

For many years, physicians at clinics abroad have been treating metastatic prostate cancer with hormonal drugs. Hormonal therapy allows doctors to control metastatic prostate cancer for several years.

Generally, prostate cancer is a hormone-dependent tumor. The more male sex hormones are in the body, the faster it grows. Treatment with medications is aimed at reducing the level of hormones and reducing the tumor’s sensitivity to them. As a result, it is possible to stop the cancer progression. The earlier one starts taking medications, the milder the symptoms will become and the less pronounced the side effects will be. But even at the last stages of prostate cancer, treatment can significantly alleviate the condition and prolong life.

Taking into consideration that most prostate tumors have hormone-sensitive cells, the combined administration of anti-androgen therapy and chemotherapy in patients with advanced prostate cancer is proven in many researches. Even though there is a search for new approaches, anti-androgen therapy remains the main method of treatment of patients with advanced prostate cancer.

The overall treatment tactics for metastatic prostate cancer depends on the degree of spread of the tumor in the patient’s body, the aggressiveness of cancer, the age of the patient, and his general health condition. In doing so, the doctor discusses with the patient all possible treatment options, the chances of a complete cure, and possible consequences or complications of certain treatment methods.

Innovative therapy options for metastatic prostate cancer

When surgical and conventional treatments aren’t possible or are no longer working, patients have the option to undergo innovative drug therapy. Drug therapy options for metastatic prostate cancer include treatments with radionuclides – Lutetium-177, Actinium-225, and Radium-223.

Lutetium-177 PSMA therapy is based on the use of a radioactive isotope of the element Lutetium. Cancer cells have a large number of receptors to a special protein – prostate-specific membrane antigen. Complexes consisting of isotope Lutetium-177 and PSMA attach to these receptors with high selectivity, which means that the main part of the radiation will affect the tumor cells.

Actinium-225 PSMA therapy acts by the same principle as the Lutetium-177 PSMA therapy. The difference here is in the use of another radioisotope – Actinium-225. Whereas Lutetium-177 emits beta particles, Actinium-225 emits alpha particles. Actinium-225 PSMA therapy is used in cases where the patient does not show a good response to radionuclide treatment with Lutetium-177.

Therapy with Radium-223 is based on the natural radioactivity of this element, which emits alpha radiation and is similar to calcium. That means that more than 80% of Radium entering our body accumulates in the bones. And consequently, it is convenient to use it for local irradiation of bone metastases. The most common drug used for treatment with Radium-223 is called Xofigo.

You can find the extended comparison of different treatment options here.

Undergoing treatment of metastatic prostate cancer during a lockdown

Even though the lockdown makes it more difficult to travel abroad for treatment, it doesn’t make it impossible. And a team of professionals will guide every step of treatment planning so that you don’t waste your time and money.

Booking Health can become a guide for you, and even beyond showing a direction, the company can organize the whole treatment. You don’t need to worry if you need a visa or you’re currently experiencing difficulties with getting one – Booking Health will help you get a visa during a lockdown no matter how difficult you think your situation is.

Feel free to leave a request on the Booking Health website to know more about treatment options for metastatic prostate cancer.


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