The crash happened just before 7 a.m. Saturday morning in the Bronx near Exit 5.
Three people were in the car that was hit.
The 27-year-old male driver and a 37-year-old female passenger suffered minor injuries and are expected to be okay.
A man in his 30s was a passenger in the backseat, he has a head injury and is not expected to survive.
Police have not released any information about the car that hit them.
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