Successive defeats for Jose Mourinho’s team have left Spurs six points adrift of the Reds, but Wolves will feel confident.
Nuno’s side defeated Tottenham 3-2 the last time the sides face each other, and are looking to win consecutive games against the north London club for the first time since 2009/10.
While Spurs are yet to lose consecutive away games under Mourinho, they are winless in their previous three.
Here’s everything you need to know about the match:
The fixture will kick off at 7:15pm GMT at Molineux Stadium.
The match will be televised on Sky Sports Premier League and Main Event, with coverage from 7pm GMT. Subscribers can also stream the game live on the Sky Sports website and SkyGo app.
Leander Dendoncker is a doubt after suffering an injury against Chelsea, while Raul Jiminez and Jonny remain absent with long-term problems.
Tanguy Ndombele will be available to face Wolves, but fellow midfielder Giovani Lo Celso is out with a hamstring injury sustained against Leicester. Loanee Gareth Bale will be assessed before kick-off after coming off in the League Cup win over Stoke with a calf injury.
Wolves XI: Rui Patricio, Semedo, Coady, Saiss, Marcal, Moutinho, Neves, Traore, Podence, Neto, Fabio Silva
Tottenham XI: Lloris, Doherty, Sanchez, Dier, Davies, Reguilon, Hojbjerg, Winks, Ndombele, Son, Kane.
Tottenham will be desperate for a win, but Wolves are a strong side that impress most against the big sides. With players that can make a difference on either team, I see no separating them at Molineux. 1-1.
This weekend get a £10 free bet with Betfair, when you bet £10 on a Same Game Multi on the Premier League. Terms: Min £10 Same Game Multi bet on any EPL match this Fri – Sun. Free bet valid for 72 hours, awarded at bet settlement. Excludes cashed out bets. T&Cs apply.